• Supports Muscular Endurance Performance: L-citrulline malate supports exercise performance and muscle endurance by enhancing nitric oxide production and supporting healthy oxygen delivery to working muscles.
• Supports Healthy Blood Flow: As a vasodilator precursor, citrulline converts to arginine and then nitric oxide, promoting healthy circulation and optimal blood vessel function throughout the body.
• Supports Cardiovascular Health: Citrulline and malate work together to support heart health by promoting healthy blood pressure already within normal range and efficient cardiovascular function.
• Supports Exercise Recovery: Studies show citrulline malate supports healthy recovery between training sessions by supporting healthy ammonia clearance and metabolism during exercise.

Research shows L-citrulline provides higher plasma arginine levels than direct arginine supplementation. A German study found that just 3 grams of citrulline produced similar benefits to 6 grams of arginine. The 2:1 ratio with malate provides enhanced stability and bioavailability, making this an efficient choice for fitness enthusiasts and anyone seeking cardiovascular support.

• 2:1 Ratio Standardization: Our L-Citrulline DL-Malate maintains a precise 2:1 ratio of citrulline to malate, verified through HPLC analysis to ensure consistent potency and enhanced stability compared to pure citrulline alone.
• Purity Verification: Each batch undergoes comprehensive testing for both product purity and identity through third-party labs, confirming the absence of contaminants and accurate ingredient composition.
• Malic Acid Enhancement: The DL-malate component provides superior bioavailability and gastric tolerance compared to standard citrulline, while supporting the Krebs cycle for enhanced energy metabolism at the cellular level.
• Pharmaceutical Grade Manufacturing: Manufactured in FDA-registered, cGMP-certified facilities to pharmaceutical standards, ensuring consistent quality and regulatory compliance for every batch produced.

• Nitric Oxide Pathway: L-citrulline bypasses first-pass liver metabolism and converts directly to arginine in the kidneys, creating a more efficient route for blood flow supplements than direct arginine supplementation.
• Malate Enhancement: The DL-malate component participates in the citric acid cycle, supporting cellular energy production while stabilizing citrulline for improved absorption and reduced degradation in the digestive system.
• Sustained Arginine Release: Unlike direct arginine supplementation which peaks rapidly and declines, citrulline provides steady plasma arginine elevation over several hours, maintaining consistent nitric oxide availability.
• Ammonia Buffering: L-citrulline helps remove excess ammonia from muscle tissue during exercise through the urea cycle, supporting healthy metabolic function during supplements for muscle growth and performance activities.

Clinical research demonstrates that L-citrulline DL-malate offers significant advantages in vascular function and exercise performance. Studies have shown that citrulline malate supplementation supports healthy vasodilation through enhanced nitric oxide production [1]. The compound’s role in the urea cycle is well-established, where citrulline helps maintain healthy ammonia clearance pathways [2][3]. Research comparing citrulline to direct arginine supplementation reveals that oral L-citrulline produces more efficient increases in plasma arginine levels, with studies showing that 3 grams of citrulline can match the bioavailability of 6 grams of arginine [4][5][6].

Buy L-Citrulline DL-Malate 2:1 Powder online

The malate component contributes to the supplement’s effectiveness through its participation in cellular energy production. Malic acid serves as an intermediate in the citric acid cycle, supporting ATP synthesis and metabolism at the cellular level. Research in animal models has demonstrated that citrulline supplementation supports exercise performance and reduces fatigue markers [7]. The 2:1 ratio of citrulline to malate provides enhanced stability and bioavailability compared to pure citrulline, while the malate fraction supports the body’s natural energy production pathways that complement fitness and performance goals.

[1] Rho S, Kang M, Choi B, et al. Nutrients. 2020;12(2):590.

[2] Imbard A, Bouchereau J, Arnoux JB, et al. Journal of Inherited Metabolic Disease. 2023;46(4):769-778.

[3] Tanaka N, Kido J, Nakamura K, et al. Pediatrics International. 2017;59(4):465-470.

[4] Schwedhelm E, Maas R, Freese R, et al. British Journal of Clinical Pharmacology. 2008;65(1):51-59.

[5] Suzuki T, Morita M, Hayashi T, Kamimura A. Bioscience, Biotechnology, and Biochemistry. 2017;81(2):372-375.

[6] Marini JC, Agarwal U, Didelija IC, et al. Journal of Nutrition. 2017;147(4):550-558.

[7] Takeda K, Machida M, Kohara A, et al. Journal of Nutritional Science and Vitaminology. 2011;57(3):246-250.

L-Citrulline DL-Malate 2:1 Powder:

• L-Citrulline DL-Malate (2:1 ratio)
• 3000mg per serving
• Pharmaceutical grade purity

The 3000mg serving size represents the clinically effective dosage established in research, providing optimal bioavailability without requiring the higher doses needed with straight arginine supplementation. Our pharmaceutical-grade sourcing ensures consistent particle size and dissolution rates, maximizing absorption efficiency for supplements for muscle growth and cardiovascular support applications.

Buy L-Citrulline DL-Malate 2:1 Powder online, Where to buy nootropics for Energy, Blood flow, Longitivity, Metabolism online Europe, Free Delivery

Frequently asked questions

1. How much L-Citrulline DL-Malate should I take daily?

   Since this powder doesn’t include a scoop, you’ll need a milligram scale for accurate measurement – we sell one at nootropicsdepot.com/nootropics-depot-milligram-scale-nds-201/. Start with 3 grams and adjust based on your response.

2. Can I stack L-Citrulline DL-Malate with pre-workout supplements?

   Yes, our L-Citrulline DL-Malate stacks well with most pre-workout supplements and can enhance their effectiveness. Since it works through nitric oxide production for blood flow support, it complements typical pre-workout ingredients like caffeine or creatine rather than competing with them.

3. How does Nootropics Depot’s 2:1 ratio compare to other brands?

   Our L-Citrulline DL-Malate uses a precise 2:1 ratio of citrulline to malate, which research shows offers superior bioavailability compared to pure citrulline alone. Many other brands use inconsistent ratios or don’t specify their exact formulation. We chose the 2:1 ratio because studies demonstrate this combination creates a more stable compound that your body can utilize more efficiently for nitric oxide production and cardiovascular support.

4. When should I take L-Citrulline DL-Malate for best results?

   Take our L-Citrulline DL-Malate 2:1 on an empty stomach once daily, either before your workout or in the morning to support cardiovascular function throughout the day. Optimal benefits typically develop over 2-3 weeks of consistent daily use as your body’s nitric oxide production pathways adapt.

5. Can I mix L-Citrulline DL-Malate powder with other supplements?

   Yes, L-Citrulline DL-Malate powder mixes well with most other supplements and is commonly stacked with pre-workout ingredients like creatine, beta-alanine, or caffeine. The powder dissolves easily in water or juice and won’t interfere with the absorption of other supplements. We recommend using a milligram scale for accurate dosing since this product doesn’t include a measuring scoop.

6. Is Nootropics Depot’s L-Citrulline DL-Malate third-party tested?

   Yes, our L-Citrulline DL-Malate 2:1 powder is third-party tested for purity and potency. We test every batch to verify the exact 2:1 ratio of citrulline to malate, and each product comes with a certificate of analysis available upon request.

7. Can you take 9000mg Citrulline Malate daily?

   Our L-Citrulline DL-Malate 2:1 is typically dosed at 3-6 grams daily, though studies have used up to 8 grams without adverse effects, making 9 grams on the higher end of research ranges. We recommend starting with 3 grams to assess tolerance. For precise powder measurement, we recommend using a milligram scale available at nootropicsdepot.com/nootropics-depot-milligram-scale-nds-201/

8. What is Citrulline Malate?

   L-Citrulline DL-Malate combines the amino acid L-citrulline with malic acid in a 2:1 ratio, creating a more stable and bioavailable form than citrulline alone. Your body converts citrulline into arginine, which then produces nitric oxide to support healthy cardiovascular function and blood flow. The malate component enhances absorption and supports cellular energy production for exercise performance.